Synthesis and Pharmacological Properties of Oxytocin Analogues Modified Simultaneously in Position 2 and in the Disulfide Bridge*
نویسندگان
چکیده
Analogues of deamino-ti-carba-oxytocin, containing isoleucine, Ocmethyltyrosine or methionine in position 2, either in the sulfide or sulfoxide form, were prepared and studied pharmacologically. These compounds had considerably lower biological activities than the analogous compounds of the l-carba series. Furthermore, analogues of [l,6-homolanthionine]deamino-oxytocin were prepared with Ocmethyltyrosine or isoleucine in position 2; these compounds had a certain degree of oxytocic activity.
منابع مشابه
The Synthesis and Pharmacological Study of 4-decarboxamido-oxytocin (4-alpha-aminobutyric Acid-oxytocin) and 5-decarboxamido-oxytocin (5-alanine-oxytocin).
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